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Antiproliferative Triterpenes from Melaleuca ericifolia
Department of Basic Pharmaceutical Sciences, College of Pharmacy, University of Louisiana at Monroe, 700 University Avenue, Monroe, Louisiana 71209, and Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt
J. Nat. Prod., 2008, 71 (10), pp 1787–1790
Publication Date (Web): October 1, 2008
Three new 28-norlupane triterpenes, 28-norlup-20(29)-en-3β-hydroxy-17β-hydroperoxide (1), 28-norlup-20(29)-en-3β-hydroxy-17α-hydroperoxide (2), and 20S-17β,29-epoxy-28-norlupan-3β-ol (3), were isolated from the leaves of Melaleuca ericifolia along with eight known pentacyclic triterpenes. The structures of the new compounds were elucidated by spectroscopic methods including 1D and 2D NMR spectroscopy and mass spectrometry. The isolated triterpenes were evaluated for antiproliferative activity against the malignant +SA mammary epithelial cell line.